One of the pathologies that generates the most pharmaceutical drugs worldwide is chronic sadness, known medically as depression. Following a personal episode in which María Ruido took antidepressants for a time, this researcher and visual artist has constructed a filmic essay that fully takes on board Foucault’s theory on the social construction of depression. Ruido incorporates groups that offer support to sufferers, together with the conceptual analysis of Mark Fischer, Santiago López Petit, Franco Berardi ‘Bifo’ and Guillermo Rendueles. The intimate and private experience arising from uncertainty, job insecurity and extreme individualism is precisely where the social regime of capitalism has left us. Estado del malestar (State of Unease) is one of the recent additions to the MACBA Collection.