Mirtha Dermisache was born in 1940 in Buenos Aires, where she studied Visual Art. In 1966 she published her first book: 500 pages elaborated as a strictly visual exercise without any semantic content. Following this first venture into Asemic writing, her work has continued to be constructed from random graphics reminiscent of scribbles, while over the years she has acquired her own form of aesthetics by organising her indecipherable graphics and writings into texts, letters and books. Her work has been praised by renowned linguistics theorists such as Roland Barthes.

Since 2004, a significant part of her production has been published by the artist in collaboration with the French publisher Florent Fajole. Dermisache's work has been shown at the Fondation nationale des arts graphiques et plastiques, Paris (1980); Centrale Bibliotheek van de Rijksuniversiteit, Ghent (1988); Fundación San Telmo, Buenos Aires (1988); Neues Museum Weserburg, Bremen (1994); and Centro Cultural Recoleta, Buenos Aires (2001). Her work is included in collections such as the Museo de Arte Moderno, Buenos Aires; Museo Nacional Centro de Arte Reina Sofía, Madrid; Centre Georges Pompidou, Paris; Bibliothèque Kandinsky, Paris; Stedelijk Museum, Amsterdam; and MACBA, Barcelona, among others.